The British vote to leave the European Union (EU) has introduced a new political dynamic in Europe. For lack of a better term, let’s call it ‘disintegration’. The problem is that we know very little about the many different motivations and other forces at work. Disintegration is not integration in reverse. We cannot simply take the many different models or interpretations of what brought European countries together and run them backward to understand events as they are unfolding. We cannot use past experience as much of a guide to anticipate future events or developments either. Lacking a coherent theory of disintegration, we are left to rely primarily on guesswork. Given how most commentators performed in forecasting Britain’s vote to leave the EU, my suspicion is that much of that guesswork will prove inaccurate. We are still sailing in uncharted waters.